Brand  (β version)

PDB ID: 4EHR

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Ligands
Code Name Style Show Link
0Q5 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1h)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide PoSSuM
IMD Imidazole PoSSuM
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Structure summary

Code : 4EHR   PDBj   RCSB PDB   PDBe
Header : APOPTOSIS
Title : Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-N-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
Release Data : 2012-06-06
Compound :
mol_id molecule chains synonym
1 Bcl-2-like protein 1 A Bcl2-L-1, Apoptosis regulator Bcl-X
fragment: UNP RESIDUES 1-209
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: BCL2L1, BCL2L, BCLX
expression_system_strain: HMS174 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PET29B
Authors : Schroeder, G.M., Wei, D., Banfi, P., Cai, Z., Lippy, J., Menichincheri, M., Modugno, M., Naglich, J., Penhallow, B., Perez, H.L., Sack, J., Schmidt, R.J., Tebben, A., Yan, C., Zhang, L., Galvani, A., Lombardo, L.J., Borzilleri, R.M.
Keywords : apoptosis, programmed cell death, bcl-2 family
Exp. method : X-RAY DIFFRACTION ( 2.09 Å )
Citation :

Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.

Schroeder, G.M.,Wei, D.,Banfi, P.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 3951 - 3956

PubMed: 22608393
DOI: 10.1016/j.bmcl.2012.04.106

Reaction

Chain : A
UniProt : Q07817 (B2CL1_HUMAN)
Reaction : -