Brand  (β version)

PDB ID: 4EH5

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0OM Benzyl pyridine-3-carboxylate PoSSuM
IRG N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4EH5   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase inhibitor
Title : Human p38 MAP kinase in complex with NP-F4 and RL87
Release Data : 2012-12-05
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX 6P-1
Authors : Over, B., Gruetter, C., Waldmann, H., Rauh, D.
Keywords : MAP Kinase Insert, Kinase-Ligand Complex, NP-Fragment, Transferase-Transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Natural-product-derived fragments for fragment-based ligand discovery.

Over, B.,Wetzel, S.,Grutter, C.  et al.
(2012)  Nat Chem  5 : 21 - 28

PubMed: 23247173
DOI: 10.1038/nchem.1506

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590