Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0P8 2-({3-[(3,5-dibromo-2-methoxybenzyl)amino]propyl}amino)quinolin-4(1h)-one
DMS Dimethyl sulfoxide
GOL Glycerol
MET Methionine
SO4 Sulfate ion
Modified Residues
Code Name Link
CAS S-(dimethylarsenic)cysteine
Code : 4EGA
Header : LIGASE/LIGASE INHIBITOR
Title : Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320
Release Data : 2012-09-12
Compound :
mol_id molecule chains
1 Methionyl-tRNA synthetase, putative A,B
ec: 6.1.1.10
fragment: RESIDUES 235-773
mutation: K452A, K453R, E454A
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei brucei  (taxid:999953) Escherichia coli  (taxid:469008)
strain: 927/4 GUTat10.1
gene: Tb10.70.6470
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: AVA0421
Authors : Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Keywords : aminoacyl-tRNA synthetase, aaRS, MetRS, parasite, ligase, protein-inhibitor complex, Rossmann-fold, translation, nucleotide binding, Rossmann Fold, tRNA binding, ATP binding, LIGASE-LIGASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.698 Å )
Citation :

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.

Koh, C.Y.,Kim, J.E.,Shibata, S.  et al.
(2012)  Structure  20 : 1681 - 1691

PubMed: 22902861
DOI: 10.1016/j.str.2012.07.011

Chain : A, B
UniProt : Q38C91 (No found in current UniProtKB/SwissProt)
Reaction : -