Brand  (β version)

PDB ID: 4EFB

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Ligands
Code Name Style Show Link
0OW 4-amino-2-(cyclopentyloxy)-6-{[(1r,2s)-2-hydroxycyclopentyl]oxy}pyrimidine-5-carboxamide PoSSuM
NMN Beta-nicotinamide ribose monophosphate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4EFB   PDBj   RCSB PDB   PDBe
Header : ligase/ligase inhibitor
Title : Crystal structure of DNA ligase
Release Data : 2013-04-03
Compound :
mol_id molecule chains synonym
1 DNA ligase A Polydeoxyribonucleotide synthase [NAD(+)]
ec: 6.5.1.2
Source :
mol_id organism_scientific
1 Enterococcus faecalis  (taxid:1351)
synthetic: yes
other_details: This sequence occurs naturally in bacterial
Authors : Wei, Y., Wang, T., Charifson, P., Xu, W.
Keywords : alpha-beta protein, enzyme, adenylation, ligase-ligase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystal structure of DNA ligase

Wang, T.,Charifson, P.,Xu, W.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q837V6 (DNLJ_ENTFA)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta- nicotinamide D-nucleotide. 6.5.1.2 HAMAP-Rule:MF_01588
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Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_01588
ECO:0000255 | HAMAP-Rule:MF_01588
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