Het-PDB Navi2 (PDB: 4EB3)

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Ligands
Code	Name		Style	Show	Link
SF4	Iron/sulfur cluster				PoSSuM
0O3	3-(hydroxymethyl)but-3-en-1-yl trihydrogen diphosphate				PoSSuM

Non-standard Residues
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Download interaction data: 4EB3

Code :

4EB3 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of IspH in complex with iso-HMBPP

Release Data :

2013-02-06

Compound :

mol_id	molecule	chains	synonym
1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	A,B	IspH
	ec: 1.17.1.2

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: ispH, lytB, yaaE, b0029, JW0027 expression_system_strain: XL1 blue expression_system_vector_type: plasmid expression_system_plasmid: pQE30

Authors :

Wang, W., Wang, K., Span, I., Bacher, A., Groll, M., Oldfield, E.

Keywords :

iron-sulfur protein, reductase, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP), OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.

Wang, W.,Wang, K.,Span, I. et al.
(2012) J.Am.Chem.Soc. 134 : 11225 - 11234

Chain :

A, B

UniProt :

P62623 (ISPH_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]- [ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]	1.17.7.4	PubMed:12198182, PubMed:12571359, PubMed:12706830
	-	PubMed:12198182, PubMed:12571359, PubMed:12706830
dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]- [ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]	1.17.7.4	PubMed:12198182, PubMed:12571359, PubMed:12706830
	-	PubMed:12198182, PubMed:12571359, PubMed:12706830

PDB ID: 4EB3