Brand  (β version)

PDB ID: 4EA3

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Ligands
Code Name Style Show Link
0NN 1-benzyl-N-[3-(1'H,3h-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide PoSSuM
OLB (2s)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
OLA Oleic acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4EA3   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic
Release Data : 2012-04-25
Compound :
mol_id molecule chains synonym
1 Fusion protein of Nociceptin receptor and cytochrome b562 A,B OP4, KOR-3, ORL1, NOCICEPTIN/ORPHANIN FQ RECEPTOR, Cytochrome b-562
mutation: M29W, H124I, K128L
Source :
mol_id organism_scientific expression_system
1 Homo Sapiens  (taxid:9606) Spodoptera frugiperda  (taxid:7108)
gene: OOR, OPRL1, ORL1, cybC
expression_system_strain: Sf9
expression_system_vector_type: pFastBac1
Authors : Thompson, A.A., Liu, W., Chun, E., Katritch, V., Wu, H., Vardy, E., Huang, X.P., Trapella, C., Guerrini, R., Calo, G., Roth, B.L., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Keywords : PSI-biology GPCR network, Structural Genomics, GPCR membrane protein 7TM NOP ORL1 cytochrome b562, receptor, nociceptin orphanin FQ compound 24 opioid, fusion, membrane transmembrane, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.013 Å )
Citation :

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Thompson, A.A.,Liu, W.,Chun, E.  et al.
(2012)  Nature  485 : 395 - 399

PubMed: 22596163
DOI: 10.1038/nature11085

Reaction

Chain : A, B
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -
Cofactor: Evidence: Note:
heme b - Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.
Chain : A, B
UniProt : P41146 (OPRX_HUMAN)
Reaction : -