Het-PDB Navi2 (PDB: 4E73)

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Ligands
Code	Name		Style	Show	Link
0NR	Methyl 3-(4-{[(1r,2s,3s,5s,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate				PoSSuM

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Glycosylation
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Download interaction data: 4E73

Code :

4E73 PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor

Release Data :

2013-05-29

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 8	A	MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1
	ec: 2.7.11.24

mol_id	molecule	chains	synonym
2	C-Jun-amino-terminal kinase-interacting protein 1	B	JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: MAPK8, JNK1, PRKM8, SAPK1, SAPK1C expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Lukacs, C.M., Janson, C.A.

Keywords :

Kinase, Transferase-Transferase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.27 Å )

Citation :

Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.

Haynes, N.E.,Scott, N.R.,Chen, L.C. et al.
(2012) ACS Med Chem Lett 3 : 764 - 768

Chain :

UniProt :

P45983 (MK08_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	PubMed:10747973, PubMed:10856240, PubMed:11062067, PubMed:15141161, PubMed:16581800, PubMed:17296730, PubMed:17875713, PubMed:18307971, PubMed:19166818, PubMed:20027304, PubMed:21095239, PubMed:21364637, PubMed:21660049, PubMed:21856198, PubMed:22441692, PubMed:22966201, PubMed:27568560, PubMed:28943315, PubMed:8654373
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	PubMed:10747973, PubMed:10856240, PubMed:11062067, PubMed:15141161, PubMed:16581800, PubMed:17296730, PubMed:17875713, PubMed:18307971, PubMed:19166818, PubMed:20027304, PubMed:21095239, PubMed:21364637, PubMed:21660049, PubMed:21856198, PubMed:22441692, PubMed:8654373
	-

PDB ID: 4E73