Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0ND [({[2-chloro-4-(1h-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid
PO4 Phosphate ion
Code : 4E3M
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of AmpC beta-lactamase in complex with a 2-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor
Release Data : 2012-09-26
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A,B Cephalosporinase
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: ampA, ampC, b4150, JW4111
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: POGO295
Authors : Eidam, O., Shoichet, B.K.
Keywords : AMPC beta-lactamase, class C, cephalosporinase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.4400 Å )
Citation :

Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo.

Eidam, O.,Romagnoli, C.,Dalmasso, G.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 17448 - 17453

PubMed: 23043117
DOI: 10.1073/pnas.1208337109

Chain : A, B
UniProt : P00811 (AMPC_ECOLI)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.