Het-PDB Navi2 (PDB: 4E3J)

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Ligands
Code	Name		Style	Show	Link
0N4	[({[4-(1h-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid				PoSSuM
PO4	Phosphate ion				PoSSuM

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Download interaction data: 4E3J

Code :

4E3J PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl benzene sulfonamide boronic acid inhibitor

Release Data :

2012-09-26

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	A,B	Cephalosporinase
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: ampA, ampC, b4150, JW4111 expression_system_strain: JM109 expression_system_vector_type: plasmid expression_system_plasmid: POGO295

Authors :

Eidam, O., Shoichet, B.K.

Keywords :

AMPC beta-lactamase, class c, hydrolase, cephalosporinase, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.7999 Å )

Citation :

Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo.

Eidam, O.,Romagnoli, C.,Dalmasso, G. et al.
(2012) Proc.Natl.Acad.Sci.USA 109 : 17448 - 17453

Chain :

A, B

UniProt :

P00811 (AMPC_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10102
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10102

PDB ID: 4E3J