Brand  (β version)

PDB ID: 4DV8

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Ligands
Code Name Style Show Link
0LX (2s)-6-[(4-fluorobenzyl)amino]-2-[(2r)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide PoSSuM
MLI Malonate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4DV8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
Release Data : 2012-03-14
Compound :
mol_id molecule chains synonym
1 Lethal factor A LF, Anthrax lethal toxin endopeptidase component
ec: 3.4.24.83
Source :
mol_id organism_scientific organism_common expression_system
1 Bacillus anthracis  (taxid:1392) Anthrax,anthrax bacterium Escherichia coli  (taxid:562)
gene: lef, pXO1-107, BXA0172, GBAA_pXO1_0172
Authors : Margosiak, S.A., Sankaran, B.
Keywords : endopeptidase, Zinc dependent, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.632 Å )
Citation :

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.

Jiao, G.S.,Kim, S.,Moayeri, M.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 2242

PubMed: 22342144
DOI: 10.1016/j.bmcl.2012.01.095

Reaction

Chain : A
UniProt : P15917 (LEF_BACAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases. 3.4.24.83 PubMed:14718925, PubMed:9563949
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