Brand  (β version)

PDB ID: 4DT2

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FE Fe (III) ion PoSSuM
GOL Glycerol PoSSuM
0LV (2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methanol PoSSuM
SO4 Sulfate ion PoSSuM
ACT Acetate ion PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show

Structure summary

Code : 4DT2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC27209
Release Data : 2012-09-19
Compound :
mol_id molecule chains
1 Purple acid phosphatase A,B,C,D
ec: 3.1.3.2
Source :
mol_id organism_scientific organism_common
1 Phaseolus vulgaris  (taxid:3885) French bean,kidney bean,string bean
gene: pap
Authors : Feder, D., Hussein, W.M., Clayton, D.J., Kan, M., Schenk, G., McGeary, R.P., Guddat, L.W.
Keywords : phosphatase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.

Feder, D.,Hussein, W.M.,Clayton, D.J.  et al.
(2012)  Chem.Biol.Drug Des.  80 : 665 - 674

PubMed: 22943065
DOI: 10.1111/cbdd.12001

Reaction

Chain : A, B, C, D
UniProt : O24319 (PPAF_PHAVU)
Reaction: EC: Evidence:
Physiological Direction:
a phosphate monoester + H2O = an alcohol + phosphate 3.1.3.2 PubMed:12054466, PubMed:22943065
-
Cofactor: Evidence: Note:
Fe cation - Binds 1 Fe cation per subunit.
Zn(2+) - Binds 1 zinc ion per subunit.