Brand  (β version)

PDB ID: 4DST

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Ligands
Code Name Style Show Link
9LI 2-(4,6-dichloro-2-methyl-1h-indol-3-yl)ethanamine PoSSuM
ACT Acetate ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
GCP Phosphomethylphosphonic acid guanylate ester PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4DST   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Release Data : 2012-04-04
Compound :
mol_id molecule chains synonym
1 GTPase KRas, isoform 2B A KRas 4B, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed
ec: 3.6.-.-
mutation: G12D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KRAS, KRAS2, RASK2
Authors : Oh, A., Maurer, T., Garrenton, L.S., Pitts, K., Anderson, D.J., Skelton, N.J., Fauber, B.P., Pan, B., Malek, S., Stokoe, D., Ludlam, M., Bowman, K.K., Wu, J., Giannetti, A.M., Starovasnik, M.A., Mellman, I., Jackson, P.K., Ruldolph, J., Fang, G., Wang, W.
Keywords : Small G-protein, Signaling, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Maurer, T.,Garrenton, L.S.,Oh, A.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 5299 - 5304

PubMed: 22431598
DOI: 10.1073/pnas.1116510109

Reaction

Chain : A
UniProt : P01116 (RASK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) 3.6.5.2 PubMed:20949621, PubMed:39809765
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