PDB ID: 4DRU
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0LN | 13-cyclohexyl-3-methoxy-17,22-dimethyl-7h-10,6-(methanoiminothioiminobutanoiminomethano)indolo[2,1-a][2]benzazepine-14,23-dione 16,16-dioxide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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Download interaction data: 4DRU
Structure summary
Code : | 4DRU PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Transferase/Inhibitor | ||||||||||||
Title : | HCV NS5B in complex with macrocyclic INDOLE INHIBITOR | ||||||||||||
Release Data : | 2012-04-18 | ||||||||||||
Compound : |
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Authors : | Cummings, M.D., Vendeville, S. | ||||||||||||
Keywords : | HCV POLYMERASE, macrocycle inhibitor, thumb domain, Transferase-Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.10 Å ) | ||||||||||||
Citation : |
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Cummings, M.D.,Lin, T.I.,Hu, L.
et al.
PubMed: 22473861 |
Reaction
Chain : | A, B | ||||||||||||||||||||
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UniProt : | O92972 (POLG_HCVJ4) | ||||||||||||||||||||
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