PDB ID: 4DK5
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0KO | 4-(2-[(6-methoxypyridin-3-yl)amino]-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 4DK5
Structure summary
Code : | 4DK5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Transferase/Inhibitor | ||||||||||||
Title : | Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor | ||||||||||||
Release Data : | 2012-05-16 | ||||||||||||
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Authors : | Whittington, D.A., Tang, J., Yakowec, P. | ||||||||||||
Keywords : | phosphotransferase, cancer, p85-alpha, p85-beta, Ras, Transferase-Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.950 Å ) | ||||||||||||
Citation : |
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Smith, A.L.,D'Angelo, N.D.,Bo, Y.Y.
et al.
PubMed: 22548365 |
Reaction
Chain : | A | |||||||||||||||||||||||
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UniProt : | P48736 (PK3CG_HUMAN) | |||||||||||||||||||||||
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