Brand  (β version)

PDB ID: 4DJH

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
JDC (3r)-7-hydroxy-N-{(2s)-1-[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide PoSSuM
CIT Citric acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4DJH   PDBj   RCSB PDB   PDBe
Header : Hormone receptor/antagonist
Title : Structure of the human kappa opioid receptor in complex with JDTic
Release Data : 2012-03-21
Compound :
mol_id molecule chains synonym
1 Kappa-type opioid receptor, Lysozyme A,B K-OR-1, KOR-1
fragment: UNP P41145 residues 43-261, UNP P00720 residues 2-161, UNP P41145 residues 362-358
mutation: I135L, C54T, C97A
Source :
mol_id organism_scientific organism_common expression_system
1 Enterobacteria phage T4  (taxid:10665) Human, Bacteriophage T4 Spodoptera frugiperda  (taxid:7108)
gene: OPRK, OPRK1, OPRK, e
expression_system_vector_type: plasmid
expression_system_plasmid: pFastBac1
Authors : Wu, H., Wacker, D., Katritch, V., Mileni, M., Han, G.W., Vardy, E., Liu, W., Thompson, A.A., Huang, X.P., Carroll, F.I., Mascarella, S.W., Westkaemper, R.B., Mosier, P.D., Roth, B.L., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Keywords : JDtic, GPCR newtork, PSI-Biology, KOR, hKOR, KOP, Structural Genomics, Protein Structure Initiative, GPCR Network, G-protein coupled receptor, GPCR, 7TM, kappa opioid receptor, dynorphin, membrane protein, transmembrane, Hormone receptor, Hydrolase, Hormone receptor-antagonist complex
Exp. method : X-RAY DIFFRACTION ( 2.900 Å )
Citation :

tructure of the human kappa-opioid receptor in complex with JDTic

Wu, H.,Wacker, D.,Mileni, M.  et al.
(2012)  Nature  485 : 327 - 332

PubMed: 22437504
DOI: 10.1038/nature10939

Reaction

Chain : A, B
UniProt : P41145 (OPRK_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
-