Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ZN Zinc ion
FE Fe (III) ion
0K7 2-(4-methylphenyl)-1,3-thiazole-4-carboxylic acid
GOL Glycerol
SO4 Sulfate ion
EDO 1,2-ethanediol
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show
Code : 4DHL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123
Release Data : 2012-12-12
Compound :
mol_id molecule chains
1 Purple acid phosphatase A,B,D,C
ec: 3.1.3.2
Source :
mol_id organism_scientific organism_common
1 Phaseolus vulgaris  (taxid:3885) French bean,kidney bean,string bean
Authors : Feder, D., Clayton, D.J., Hussein, W.M., Schenk, G., McGeary, R., Guddat, L.W.
Keywords : Catalytic C domain, N terminal domain, Phosphatase, Acid Phosphatase, Phosphoric Monoester Hydrolases, Hydrolase, MO07123, Maybridge, Fragment, lysosome
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.

Feder, D.,Hussein, W.M.,Clayton, D.J.  et al.
(2012)  Chem.Biol.Drug Des.  80 : 665 - 674

PubMed: 22943065
DOI: 10.1111/cbdd.12001

Chain : A, B, D, C
UniProt : O24319 (PPAF_PHAVU)
Reaction: EC: Evidence:
Physiological Direction:
a phosphate monoester + H2O = an alcohol + phosphate 3.1.3.2 PubMed:12054466, PubMed:22943065
-