Het-PDB Navi2 (PDB: 4DFN)

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Ligands
Code	Name		Style	Show	Link
0K1	3-amino-6-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]-N-[(1r,2r,3s,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide				PoSSuM

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Download interaction data: 4DFN

Code :

4DFN PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor

Release Data :

2012-04-25

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase SYK	A	Spleen tyrosine kinase
	ec: 2.7.10.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: SYK

Authors :

Lopez, M., Segarra, V., Vidal, B., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M., Nagel, S., Schreiner, P.

Keywords :

PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.4800 Å )

Citation :

Pyrazine-based Syk kinase inhibitors.

Forns, P.,Esteve, C.,Taboada, L. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 2784 - 2788

Chain :

UniProt :

P43405 (KSYK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
	-	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301

PDB ID: 4DFN