PDB ID: 4DFG
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0JV | Methyl N-[(3s,3ar,5r,6ar)-5-[[(2s,3r)-4-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]-3-oxidanyl-1-phenyl-butan-2-yl]carbamoyloxy]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[B]furan-3-yl]carbamate | PoSSuM | |||
CL | Chloride ion | PoSSuM | |||
NA | Sodium ion | PoSSuM |
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Download interaction data: 4DFG
Structure summary
Code : | 4DFG PDBj RCSB PDB PDBe | ||||||||||||
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Header : | hydrolase/hydrolase inhibitor | ||||||||||||
Title : | Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A | ||||||||||||
Release Data : | 2012-03-21 | ||||||||||||
Compound : |
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Authors : | Wang, Y.-F., Agniswamy, J., Weber, I.T. | ||||||||||||
Keywords : | aspartic acid protease, HIV-1 protease inhibitor GRL-0249A, Cyclopentyltetrahydro- furanyl Urethanes P2-ligands, wild-type HIV-1 protease, hydrolase-hydrolase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.23 Å ) | ||||||||||||
Citation : |
Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.
Ghosh, A.K.,Chapsal, B.D.,Steffey, M.
et al.
PubMed: 22364812 |
Reaction
Chain : | A, B | ||||||||||||||||||||||||
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UniProt : | P03367 (POL_HV1BR) | ||||||||||||||||||||||||
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