Brand  (β version)

PDB ID: 4DEI

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Ligands
Code Name Style Show Link
0JL 3-{(1s)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl}-5-(3-methyl-1,2-thiazol-5-yl)-3,5-dihydro-4h-[1,2,3]triazolo[4,5-C]pyridin-4-one PoSSuM
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Structure summary

Code : 4DEI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of C-Met in complex with triazolopyridinone inhibitor 24
Release Data : 2012-05-30
Compound :
mol_id molecule chains synonym
1 Hepatocyte growth factor receptor A HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: MET
expression_system_vector_type: baculovirus
Authors : Whittington, D.A., Long, A.M.
Keywords : proto-oncogene, inhibitor, receptor tyrosine kinase, RTK, ATP-binding, hepatocyte growth factor/scatter factor, HGF/SF, phosphoprotein, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.

Bode, C.M.,Boezio, A.A.,Albrecht, B.K.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 4089 - 4093

PubMed: 22595176
DOI: 10.1016/j.bmcl.2012.04.072

Reaction

Chain : A
UniProt : P08581 (MET_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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