Brand  (β version)

PDB ID: 4DAW

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Ligands
Code Name Style Show Link
0H2 [1,3-dioxo-6-(pyridin-2-yl-kappan)-2,3-dihydro-1h-isoindol-5-yl-kappac~5~][(thioxomethylidene)azanido-kappan](1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 4DAW   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex
Release Data : 2012-03-14
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PAK 1 A Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK
ec: 2.7.11.1
fragment: unp residues 249-545
mutation: K299R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PAK1
expression_system_strain: BL21(DE3)
Authors : Maksimoska, J., Marmorstein, R.
Keywords : Serine/threonine kinase, phosphorylation, ATP-binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

The art of filling protein pockets efficiently with octahedral metal complexes.

Blanck, S.,Maksimoska, J.,Baumeister, J.  et al.
(2012)  Angew.Chem.Int.Ed.Engl.  51 : 5244 - 5246

PubMed: 22383326
DOI: 10.1002/anie.201108865

Reaction

Chain : A
UniProt : Q13153 (PAK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:10551809, PubMed:20417602, PubMed:22153498, PubMed:9032240
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10551809, PubMed:22153498, PubMed:9032240
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