Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0H7 (3r)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol
SO4 Sulfate ion
Code : 4DA5
Header : Transferase/Transferase Inhibitor
Title : Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Release Data : 2013-04-17
Compound :
mol_id molecule chains synonym
1 Choline kinase alpha A,B CK, CHETK-alpha, Ethanolamine kinase;, EK
ec: 2.7.1.32, 2.7.1.82
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: CHKA, CHK, CKI
expression_system_strain: BL21(DE3)
expression_system_vector_type: modified pET28a
Authors : Brown, K., Hudson, C., Charlton, P., Pollard, J.
Keywords : kinase, signal transduction, cytoplasmic, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Kinetic and mechanistic characterisation of Choline Kinase-alpha.

Hudson, C.S.,Knegtel, R.M.,Brown, K.  et al.
(2013)  Biochim.Biophys.Acta  1834 : 1107 - 1116

PubMed: 23416529
DOI: 10.1016/j.bbapap.2013.02.008

Chain : A, B
UniProt : P35790 (CHKA_HUMAN)
Reaction : ATP + choline = ADP + phosphocholine.
ATP + ethanolamine = ADP + O- phosphoethanolamine.