Het-PDB Navi2 (PDB: 4D8A)

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Color scheme of protein:

Ligands
Code	Name	Link
LYS	Lysine	PoSSuM
SO4	Sulfate ion	PoSSuM
0HY	Methyl (3r)-3-(7-amino-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-C]pyridazin-3-yl)butanoate	PoSSuM

Non-standard Residues
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Download interaction data: 4D8A

Code :

4D8A PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of B. anthracis DHPS with compound 21

Release Data :

2012-04-04

Compound :

mol_id	molecule	chains
1	Dihydropteroate synthase	A,B
	ec: 2.5.1.15

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bacillus anthracis (taxid:191218)	Anthrax	Escherichia coli (taxid:469008)
	strain: A2012 gene: folP expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Hammoudeh, D., Lee, R.E., White, S.W.

Keywords :

TIM Barrel, TIM narrel, Synthase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.183 Å )

Citation :

Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity.

Zhao, Y.,Hammoudeh, D.,Yun, M.K. et al.
(2012) Chemmedchem 7 : 861 - 870

PDB ID: 4D8A