Brand  (β version)

PDB ID: 4D76

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
J1J N-[(2s)-1-({5-[(diaminomethylidene)amino]pentyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4D76   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human FXIa in complex with small molecule inhibitors.
Release Data : 2016-01-20
Compound :
mol_id molecule chains synonym
1 COAGULATION FACTOR XI A FXI, PLASMA THROMBOPLASTIN ANTECEDENT, PTA, COAGULATION FACTOR XIA
ec: 3.4.21.27
fragment: CATALYTIC DOMAIN, RESIDUES 388-625
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN KOMAGATAELLA PASTORIS  (taxid:4922)
Authors : Sandmark, J., Oster, L., Jacso, T., Ullah, V., Redzick, A., Borjesson, U., Olsson, T., Norberg, M., Akerud, T.
Keywords : HYDROLASE, SERINE PROTEASE
Exp. method : X-RAY DIFFRACTION ( 1.77 Å )
Citation :

From Mm Fragments to Nm Compounds Using Iloe-NMR to Guide Linking of Compounds in Fragment Based Drug Discovery (Fbdd).

Jacso, T.,Ullah, V.,Sandmark, J.  et al.
To be Published 

Reaction

Chain : A
UniProt : P03951 (FA11_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. 3.4.21.27 -
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