Brand  (β version)

PDB ID: 4D4M

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Ligands
Code Name Style Show Link
BKV 7-(4-bromophenyl)-5-phenyl-3,7-dihydro-4h-pyrrolo[2,3-D]pyrimidin-4-one PoSSuM
PHS Phosphonic acid PoSSuM
PO4 Phosphate ion PoSSuM
F6P 6-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Structure summary

Code : 4D4M   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : human PFKFB3 in complex with a pyrrolopyrimidone compound
Release Data : 2016-01-20
Compound :
mol_id molecule chains synonym
1 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3 A 6PF-2-K/FRU-2,6-P2ASE 3,PFK/FBPASE 3,PFKFB3,6PF-2-K/FRU-2\,6-P2ASE BRAIN/PLACENTA-TYPE ISOZYME, RENAL CARCINOMA ANTIGEN NY-REN-56,IPFK-2,6-PHOSPHOFRUCTO-2-KINASE, FRUCTOSE-2\,6-BISPHOSPHATASE
ec: 2.7.1.105, 3.1.3.46
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
Authors : Stgallay, S.A., Bennett, N., Critchlow, S., Davies, G., Debreczeni, J.E., Evans, N., Holdgate, G., Jones, N.P., Leach, L., Maman, S., McLoughlin, S., Preston, M., Rigoreau, L., Thomas, A., Walker, G., Walsch, J., Ward, R.A., Wheatley, E., Winter, J.
Keywords : TRANSFERASE, SUGAR KINASE, WARBURG EFFECT, ONCOLOGY
Exp. method : X-RAY DIFFRACTION ( 2.32 Å )
Citation :

Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods

Stgallay, S.A.,Bennett, N.,Critchlow, S.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q16875 (F263_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.46 PubMed:16316985, PubMed:17499765, PubMed:22275052
left-to-right PubMed:16316985
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+) 2.7.1.105 PubMed:10077634, PubMed:17499765, PubMed:16316985
left-to-right PubMed:10077634