Brand  (β version)

PDB ID: 4D44

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
JA3 5-ethyl-4-fluoro-2-[(2-fluoropyridin-3-yl)oxy]phenol PoSSuM
GLU Glutamic acid PoSSuM
MRD (4r)-2-methylpentane-2,4-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 4D44   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of S. aureus FabI in complex with NADP and 5-ethyl- 4-fluoro-2-((2-fluoropyridin-3-yl)oxy)phenol
Release Data : 2015-03-04
Compound :
mol_id molecule chains synonym
1 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] A,B,C,D,E,F,G,H ENR, ENOYL-ACP REDUCTASE
ec: 1.3.1.10, 1.3.1.39
mutation: YES
Source :
mol_id organism_scientific expression_system
1 STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315  (taxid:158879) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PETM-11
Authors : Schiebel, J., Chang, A., Tonge, P.J., Sotriffer, C.A., Kisker, C.
Keywords : OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY, FATTY ACID BIOSYNTHESIS, LIPID SYNTHESIS, SAFABI, FABI
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.

Schiebel, J.,Chang, A.,Merget, B.  et al.
(2015)  Biochemistry  54 : 1943

PubMed: 25706582
DOI: 10.1021/BI5014358

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q7A6D8
Reaction : -