PDB ID: 4D0X
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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953 | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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PTR | O-phosphotyrosine |
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Download interaction data: 4D0X
Structure summary
Code : | 4D0X PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors | ||||||||||||
Release Data : | 2014-07-23 | ||||||||||||
Compound : |
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Source : |
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Authors : | Canevari, G., Fasolini, M., Bertrand, J., Brasca, M.G., Nesi, M., Avanzi, N., Ballinari, D., Bandiera, T., Bindi, S., Carenzi, D., Casero, D., Ceriani, L., Ciomei, M., Cirla, A., Colombo, M., Cribioli, S., Cristiani, C., Della Vedova, F., Fachin, G., Felder, E.R., Galvani, A., Isacchi, A., Mirizzi, D., Motto, I., Panzeri, A., Pesenti, E., Vianello, P., Gnocchi, P., Donati, D. | ||||||||||||
Keywords : | TRANSFERASE, DRUG DISCOVERY, PROTEIN KINASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, POLYCYTHEMIA VERA, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.82 Å ) | ||||||||||||
Citation : |
Pyrrole-3-Carboxamides as Potent and Selective Jak2 Inhibitors.
Brasca, M.G.,Nesi, M.,Avanzi, N.
et al.
PubMed: 25009002 |
Reaction
Chain : | A | ||||||||
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UniProt : | O60674 (JAK2_HUMAN) | ||||||||
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