Brand  (β version)

PDB ID: 4CX3

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
HW8 4-methyl-6-{[(3r,4r)-4-{[5-(pyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}pyridin-2-amine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4CX3   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of rat neuronal nitric oxide synthase M336V D597N mutant heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Release Data : 2014-08-13
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE, BRAIN A,B BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N -NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, NEURONAL NITRIC OXIDE SYNTHASE
ec: 1.14.13.39
fragment: HEME DOMAIN, RESIDUES 297-718
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 RATTUS NORVEGICUS  (taxid:10116) NORWAY RAT ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PCWORI
Authors : Li, H., Poulos, T.L.
Keywords : OXIDOREDUCTASE, INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.97 Å )
Citation :

Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.

Li, H.,Jamal, J.,Delker, S.L.  et al.
(2014)  Biochemistry  53 : 5272

PubMed: 25089924
DOI: 10.1021/BI500561H

Reaction

Chain : A, B
UniProt : P29476 (NOS1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 PubMed:15548660, PubMed:1712077
left-to-right PubMed:1712077