Brand  (β version)

PDB ID: 4CR5

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Ligands
Code Name Style Show Link
0TU 6-chloroquinolin-2(1h)-one PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4CR5   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design
Release Data : 2015-02-11
Compound :
mol_id molecule chains synonym
1 COAGULATION FACTOR XIA A FXI, PLASMA THROMBOPLASTIN ANTECEDENT, PTA, COAGULATION FACTOR XIA LIGHT CHAIN
ec: 3.4.21.27
fragment: CATALYTIC DOMAIN, RESIDUES 388-625
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:4922)
Authors : Sandmark, J., Oster, L., Fjellstrom, O., Akkaya, S., Beisel, H.G., Eriksson, P.O., Erixon, K., Gustafsson, D., Jurva, U., Kang, D., Karis, D., Knecht, W., Nerme, V., Nilsson, I., Olsson, T., Redzic, A., Roth, R., Tigerstrom, A.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.

Fjellstrom, O.,Akkaya, S.,Beisel, H.  et al.
(2015)  Plos One  10 : 13705

PubMed: 25629509
DOI: 10.1371/JOURNAL.PONE.0113705

Reaction

Chain : A
UniProt : P03951 (FA11_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. 3.4.21.27 PubMed:22961984
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