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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide
ORO Orotic acid
JBW 5-(4-cyano-2-methyl-1h-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide
Non-standard Residues
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Code : 4CQ8   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178
Release Data : 2014-04-30
Compound :
mol_id molecule chains
1 DIHYDROOROTATE DEHYDROGENASE A,B
other_details: RESIDUES 384-413 DELETED
Source :
mol_id organism_scientific expression_system
1 PLASMODIUM FALCIPARUM  (taxid:5833) ESCHERICHIA COLI  (taxid:562)
Authors : Rowland, P.
Keywords : OXIDOREDUCTASE, DHODH
Exp. method : X-RAY DIFFRACTION ( 1.98 Å )
Citation :

In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.

Ross, L.S.,Javier Gamo, F.,Lafuente-Monasterio, M.J.E.  et al.
(2014)  J.Biol.Chem.  289 : 17980

PubMed: 24782313
DOI: 10.1074/JBC.M114.558353

Chain : A, B
UniProt : Q54A96 (Q54A96_PLAFA)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 ARBA:ARBA00001532
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