Brand  (β version)

PDB ID: 4CJX

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Ligands
Code Name Style Show Link
9L9 (2s)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1h-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid PoSSuM
GOL Glycerol PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
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Structure summary

Code : 4CJX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor
Release Data : 2015-02-04
Compound :
mol_id molecule chains
1 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE A,B
ec: 1.5.1.5
Source :
mol_id organism_scientific expression_system
1 TRYPANOSOMA BRUCEI BRUCEI STRAIN 927/4 GUTAT10.1  (taxid:999953) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET15B
Authors : Eadsforth, T.C., Hunter, W.N.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity.

Eadsforth, T.C.,Pinto, A.,Luciani, R.  et al.
(2015)  J.Med.Chem.  58 : 7938

PubMed: 26322631
DOI: 10.1021/ACS.JMEDCHEM.5B00687

Reaction

Chain : A, B
UniProt : Q57WP0 (Q57WP0_TRYB2)
Reaction : -