Brand  (β version)

PDB ID: 4CDX

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Ligands
Code Name Style Show Link
JF0 1-(5-((3'-methyl-[1,1'-biphenyl]-4-yl)oxy)pentyl)-3-( PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4CDX   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12
Release Data : 2014-02-12
Compound :
mol_id molecule chains
1 VP1 A
mol_id molecule chains
2 VP2 B
mol_id molecule chains
3 VP3 C
mol_id molecule chains
4 VP4 D
Source :
mol_id organism_scientific expression_system
1 ENTEROVIRUS A71  (taxid:39054) CHLOROCEBUS AETHIOPS  (taxid:9534)
expression_system_common: AFRICAN GREEN MONKEY
expression_system_cell_line: VERO CELLS
mol_id organism_scientific expression_system
2 ENTEROVIRUS A71  (taxid:39054) CHLOROCEBUS AETHIOPS  (taxid:9534)
expression_system_common: AFRICAN GREEN MONKEY
expression_system_cell_line: VERO CELLS
mol_id organism_scientific expression_system
3 ENTEROVIRUS A71  (taxid:39054) CHLOROCEBUS AETHIOPS  (taxid:9534)
expression_system_common: AFRICAN GREEN MONKEY
expression_system_cell_line: VERO CELLS
mol_id organism_scientific expression_system
4 ENTEROVIRUS A71  (taxid:39054) CHLOROCEBUS AETHIOPS  (taxid:9534)
expression_system_common: AFRICAN GREEN MONKEY
expression_system_cell_line: VERO CELLS
Authors : De Colibus, L., Wang, X., Spyrou, J.A.B., Kelly, J., Ren, J., Grimes, J., Puerstinger, G., Stonehouse, N., Walter, T.S., Hu, Z., Wang, J., Li, X., Peng, W., Rowlands, D., Fry, E.E., Rao, Z., Stuart, D.I.
Keywords : VIRUS, HAND-FOOT-AND-MOUTH DISEASE, ENTEROVIRUS UNCOATING, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.

De Colibus, L.,Wang, X.,Spyrou, J.A.B.  et al.
(2014)  Nat.Struct.Mol.Biol.  21 : 282

PubMed: 24509833
DOI: 10.1038/NSMB.2769

A Sensor-Adaptor Mechanism for Enterovirus Uncoating from Structures of Ev71.

Wang, X.,Peng, W.,Ren, J.  et al.
(2012)  Nat.Struct.Mol.Biol.  19 : 424

PubMed: 22388738
DOI: 10.1038/NSMB.2255

Reaction

Chain : D
UniProt : B2ZUN0 (B2ZUN0_HE71)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 3.4.22.28 RuleBase:RU364118
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 3.4.22.29 ARBA:ARBA00024513, RuleBase:RU364118
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 ARBA:ARBA00001491, RuleBase:RU364118
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a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 RuleBase:RU364118
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