Brand  (β version)

PDB ID: 4BYI

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Ligands
Code Name Style Show Link
FH3 (S)-N-((1-(6-chloro-2-(1,3-dimethyl-1h-pyrazol-4-yl)-3h-imidazo[4,5-B]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide PoSSuM
Non-standard Residues
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Structure summary

Code : 4BYI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aurora A kinase bound to a highly selective imidazopyridine inhibitor
Release Data : 2013-11-20
Compound :
mol_id molecule chains synonym
1 AURORA KINASE A A AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THREONINE-PROTEIN KINASE AURORA-A
ec: 2.7.11.1
fragment: RESIDUES 122-403
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Joshi, A., Kosmopoulou, M., Bayliss, R.
Keywords : TRANSFERASE, CELL CYCLE, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.

Bavetsias, V.,Faisal, A.,Crumpler, S.  et al.
(2013)  J.Med.Chem.  56 : 9122

PubMed: 24195668
DOI: 10.1021/JM401115G

Reaction

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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