Brand  (β version)

PDB ID: 4BW4

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Ligands
Code Name Style Show Link
9B6 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(2-(trifluoromethoxy)phenyl)-1h-imidazo[4,5-C][1,5]naphthyridin-2(3h)-one PoSSuM
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Structure summary

Code : 4BW4   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
Release Data : 2013-09-11
Compound :
mol_id molecule chains synonym
1 BROMODOMAIN-CONTAINING PROTEIN 4 A BRD4, PROTEIN HUNK1
fragment: N-TERMINAL BROMODOMAIN, RESIDUES 44-168
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Chung, C., Mirguet, O., Lamotte, Y., Bamborough, P., Delannee, D., Bouillot, A., Gellibert, F., Krysa, G., Lewis, A., Witherington, J., Huet, P., Dudit, Y., Trottet, L., Nicodeme, E.
Keywords : TRANSCRIPTION, INHIBITOR, HISTONE, EPIGENETIC READER, ANTAGONIST
Exp. method : X-RAY DIFFRACTION ( 1.67 Å )
Citation :

Naphthyridines as Novel Bet Family Bromodomain Inhibitors.

Mirguet, O.,Lamotte, Y.,Chung, C.  et al.
(2014)  Chemmedchem  9 : 589

PubMed: 24000170
DOI: 10.1002/CMDC.201300259

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -