Brand  (β version)

PDB ID: 4BTM

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
F8E Methyl 2-bromo-5-(7h-pyrrolo[2,3-D]pyrimidin-4-ylamino)benzoate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4BTM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : TTBK1 in complex with inhibitor
Release Data : 2013-09-25
Compound :
mol_id molecule chains synonym
1 TAU-TUBULIN KINASE 1 A,B BRAIN-DERIVED TAU KINASE
ec: 2.7.11.1, 2.7.11.26
fragment: KINASE DOMAIN, RESIDUES 1-313
other_details: KINASE DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_vector_type: BACULOVIRUS
Authors : Xue, Y., Wan, P., Hillertz, P., Schweikart, F., Zhao, Y., Wissler, L., Dekker, N.
Keywords : TRANSFERASE, LIGAND COMPLEX, STRUCTURE-KINETICS RELATIONSHIP
Exp. method : X-RAY DIFFRACTION ( 2.54 Å )
Citation :

X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.

Xue, Y.,Wan, P.T.,Hillertz, P.  et al.
(2013)  Chemmedchem  8 : 1846

PubMed: 24039150
DOI: 10.1002/CMDC.201300274

Reaction

Chain : A, B
UniProt : Q5TCY1 (TTBK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:16923168
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:16923168
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