Het-PDB Navi2 (PDB: 4BQY)

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Ligands
Code	Name		Style	Show	Link
FE2	Fe (II) ion				PoSSuM
FNT	(2s)-2-{[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino}propanoic acid				PoSSuM

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Download interaction data: 4BQY

Code :

4BQY PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine

Release Data :

2013-06-19

Compound :

mol_id	molecule	chains	synonym
1	EGL NINE HOMOLOG 1	A	HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2, HIF-PH2, HIF-PROLYL HYDROXYLASE 2, HPH-2, PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2, PHD2, SM-20
	ec: 1.14.11.- fragment: CATALYTIC DOMAIN, RESIDUES 181-426

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_vector: PET28A

Authors :

Chowdhury, R., McDonough, M.A., Yeoh, K.K., Schofield, C.J.

Keywords :

OXIDOREDUCTASE, 2-OXOGLUTARATE, DIOXYGENASE, EGLN, OXYGENASE, HYPOXIA, DNA-BINDING, METAL-BINDING, TRANSCRIPTION, DSBH, FACIAL TRIAD, ASPARAGINYL/ ASPARTYL HYDROXYLASE, TRANSCRIPTION AND EPIGENETIC REGULATION, SIGNALING, DEVELOPMENT, CELL STRUCTURE, ANKYRIN REPEAT DOMAIN, ARD, BETA-HYDROXYLATION, TRANSCRIPTION ACTIVATOR/INHIBITOR, PHOSPHORYLATION, S-NITROSYLATION

Exp. method :

X-RAY DIFFRACTION ( 1.53 Å )

Citation :

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

Chowdhury, R.,Candela-Lena, J.I.,Chan, M.C. et al.
(2013) ACS Chem. Biol. 8 : 1488 - 1496

PubMed: 23683440
DOI: 10.1021/cb400088q

PDB ID: 4BQY

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