Brand  (β version)

PDB ID: 4BQH

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Ligands
Code Name Style Show Link
9VU (3s)-3-[2-(1,3-benzodioxol-5-yl)-2-oxidanylidene-ethyl]-4-bromanyl-5-methyl-3-oxidanyl-1h-indol-2-one PoSSuM
SO4 Sulfate ion PoSSuM
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Glycosylation
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Structure summary

Code : 4BQH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei in complex with inhibitor
Release Data : 2013-07-17
Compound :
mol_id molecule chains
1 UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE A
ec: 2.7.7.23
Source :
mol_id organism_scientific expression_system
1 TRYPANOSOMA BRUCEI  (taxid:5691) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: PLYSS
expression_system_vector_type: PLASMID
expression_system_vector: PGEX-6P-1
expression_system_plasmid: PGEX-6P-1-TBUAP
Authors : Fang, W., Raimi, O.G., vanAalten, D.M.F.
Keywords : TRANSFERASE, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma Brucei.

Urbaniak, M.D.,Collie, I.T.,Fang, W.  et al.
(2013)  Acs Chem.Biol.  8 : 1981

PubMed: 23834437
DOI: 10.1021/CB400411X

Reaction

Chain : A
UniProt : Q386Q8 (Q386Q8_TRYB2)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine 2.7.7.23 ARBA:ARBA00001851
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