Brand  (β version)

PDB ID: 4BO7

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Ligands
Code Name Style Show Link
J2T N-(2,3-dihydro-1h-inden-5-yl)tetrazolo[1,5-B]pyridazin-6-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4BO7   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-B)pyridazin-6-amine at 2.6A resolution
Release Data : 2013-09-18
Compound :
mol_id molecule chains synonym
1 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG A,B,C,D 3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE, BETA-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE, BETA-KETOACYL-ACP REDUCTASE, 3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE
ec: 1.1.1.100
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS AERUGINOSA  (taxid:208964) ESCHERICHIA COLI  (taxid:469008)
strain: PAO1
atcc: 47085
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PNIC28-BSA4
expression_system_plasmid: PNIC-PA2967
Authors : Cukier, C.D., Schnell, R., Lindqvist, Y., Schneider, G.
Keywords : OXIDOREDUCTASE, ROSSMANN FOLD, FATTY ACID BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa

Cukier, C.D.,Hope, A.,Elamin, A.  et al.
(2013)  Acs Chem.Biol.  8 : 2518

PubMed: 24015914
DOI: 10.1021/CB4005063

Reaction

Chain : A, B, C, D
UniProt : O54438 (FABG_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH 1.1.1.100 -
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