Brand  (β version)

PDB ID: 4BC9

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Ligands
Code Name Style Show Link
CNV Propanenitrile PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4BC9   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: WILD-TYPE, ADDUCT WITH CYANOETHYL
Release Data : 2012-11-07
Compound :
mol_id molecule chains synonym
1 ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL A,B,C,D ALKYL-DHAP SYNTHASE, ALKYLGLYCERONE-PHOSPHATE SYNTHASE
ec: 2.5.1.26
Source :
mol_id organism_scientific organism_common expression_system
1 CAVIA PORCELLUS  (taxid:10141) GUINEA PIG ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_vector: PETSUMO
Authors : Nenci, S., Piano, V., Rosati, S., Aliverti, A., Pandini, V., Fraaije, M.W., Heck, A.J.R., Edmondson, D.E., Mattevi, A.
Keywords : TRANSFERASE, PLASMALOGEN, FLAVIN, PEROXISOME
Exp. method : X-RAY DIFFRACTION ( 2.41 Å )
Citation :

Precursor of Ether Phospholipids is Synthesized by a Flavoenzyme Through Covalent Catalysis.

Nenci, S.,Piano, V.,Rosati, S.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 18791

PubMed: 23112191
DOI: 10.1073/PNAS.1215128109

Reaction

Chain : A, B, C, D
UniProt : P97275 (ADAS_CAVPO)
Reaction: EC: Evidence:
Physiological Direction:
a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) 2.5.1.26 PubMed:10692424, PubMed:23112191, PubMed:8399344, PubMed:9989261
left-to-right
hexadecan-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O- hexadecylglycerone 3-phosphate + hexadecanoate + H(+) - PubMed:10692424, PubMed:8399344, PubMed:9989261
left-to-right
1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate - UniProtKB:Q8C0I1
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:10692424
ECO:0000269 | PubMed:23112191
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