Brand  (β version)

PDB ID: 4B12

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Ligands
Code Name Style Show Link
C23 1-[3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-yl]-3-phenylpropan-1-one PoSSuM
NHW 2-oxopentadecyl-CoA PoSSuM
DMS Dimethyl sulfoxide PoSSuM
CL Chloride ion PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4B12   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23)
Release Data : 2012-10-17
Compound :
mol_id molecule chains
1 GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE A,B,C
ec: 2.3.1.97
fragment: RESIDUES 27-410
Source :
mol_id organism_scientific expression_system
1 PLASMODIUM VIVAX  (taxid:5855) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: PLYSS
expression_system_vector_type: PLASMID
expression_system_vector: PET28A
other_details: SYNTHETIC GENE
Authors : Yu, Z., Brannigan, J.A., Moss, D.K., Brzozowski, A.M., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
Keywords : TRANSFERASE, PLASMODIUM, MALARIA, DRUG DESIGN
Exp. method : X-RAY DIFFRACTION ( 1.79 Å )
Citation :

Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.

Yu, Z.,Brannigan, J.A.,Moss, D.K.  et al.
(2012)  J.Med.Chem.  55 : 8879

PubMed: 23035716
DOI: 10.1021/JM301160H

Reaction

Chain : A, B, C
UniProt : A5K1A2 (A5K1A2_PLAVS)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 RuleBase:RU000586
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