Brand  (β version)

PDB ID: 4AIG

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FLX N-[(furan-2-yl)carbonyl]-(S)-leucyl-(R)-[1-amino-2(1h-indol-3-yl)ethyl]-phosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4AIG   PDBj   RCSB PDB   PDBe
Header : METALLOENDOPEPTIDASE
Title : ADAMALYSIN II WITH PHOSPHONATE INHIBITOR
Release Data : 1998-11-11
Compound :
mol_id molecule chains
1 ADAMALYSIN II A
ec: 3.4.24.46
Source :
mol_id organism_scientific organism_common
1 Crotalus adamanteus  (taxid:8729) Eastern diamondback rattlesnake
secretion: VENOM
Authors : Pochetti, G., Mazza, F., Gavuzzo, E., Cirilli, M.
Keywords : SNAKE VENOM METALLOENDOPEPTIDASE, ZINC PROTEASE, METALLOENDOPEPTIDASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode.

Cirilli, M.,Gallina, C.,Gavuzzo, E.  et al.
(1997)  FEBS Lett.  418 : 319 - 322

PubMed: 9428736
DOI: 10.1016/S0014-5793(97)01401-4

Refined 2.0 A X-Ray Crystal Structure of the Snake Venom Zinc-Endopeptidase Adamalysin II. Primary and Tertiary Structure Determination, Refinement, Molecular Structure and Comparison with Astacin, Collagenase and Thermolysin

Gomis-Ruth, F.X.,Kress, L.F.,Kellermann, J.  et al.
(1994)  J.Mol.Biol.  239 : 513

First Structure of a Snake Venom Metalloproteinase: A Prototype for Matrix Metalloproteinases/Collagenases

Gomis-Ruth, F.X.,Kress, L.F.,Bode, W.
(1993)  Embo J.  12 : 4151

Reaction

Chain : A
UniProt : P34179 (VM12_CROAD)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15- Leu-|-Tyr-16, and 16-Tyr-|-Leu-17 of insulin B chain. 3.4.24.46 -
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