Brand  (β version)

PDB ID: 4A95

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9MT 3-(3-butyl-6-methoxy-2-methyl-quinolin-4-yl)sulfanylpropanenitrile PoSSuM
NHW 2-oxopentadecyl-CoA PoSSuM
CL Chloride ion PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4A95   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Plasmodium vivax N-myristoyltransferase with quinoline inhibitor
Release Data : 2012-06-27
Compound :
mol_id molecule chains synonym
1 GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE A,B,C N-MRISTOYLTRANSFERASE
ec: 2.3.1.97
fragment: RESIDUES 27-410
Source :
mol_id organism_scientific expression_system
1 PLASMODIUM VIVAX  (taxid:5855) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: PLYSS
expression_system_vector_type: PLASMID
expression_system_vector: PET28
other_details: SYNTHETIC GENE
Authors : Goncalves, V., Brannigan, J.A., Whalley, D., Ansell, K.H., Saxty, B., Holder, A.A., Wilkinson, A.J., Tate, E.W., Leatherbarrow, R.J.
Keywords : TRANSFERASE, MALARIA
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Discovery of Plasmodium Vivax N-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of Their Binding Mode.

Goncalves, V.,Brannigan, J.A.,Whalley, D.  et al.
(2012)  J.Med.Chem.  55 : 3578

PubMed: 22439843
DOI: 10.1021/JM300040P

Reaction

Chain : A, B, C
UniProt : A5K1A2 (A5K1A2_PLAVS)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 RuleBase:RU000586
-