Het-PDB Navi2 (PDB: 4A51)

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Ligands
Code	Name	Link
ADP	Adenosine-5'-diphosphate	PoSSuM
MG	Magnesium ion	PoSSuM
DQ8	1-(3-{[(2-aminoethyl)sulfanyl](diphenyl)methyl}phenyl)ethanone	PoSSuM
CL	Chloride ion	PoSSuM

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Download interaction data: 4A51

Code :

4A51 PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

Crystal structure of human kinesin Eg5 in complex with 1-(3-(((2-Aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride

Release Data :

2012-10-31

Compound :

mol_id	molecule	chains	synonym
1	KINESIN-LIKE PROTEIN KIF11	A,B,C,D,E,F,G	EG5, KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PROTEIN HKSP, KINESIN-RELATED MOTOR PROTEIN EG5, THYROID RECEPTOR-INTERACTING PROTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5
	fragment: MOTOR DOMAIN, RESIDUES 1-368

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_variant: PLYSS

Authors :

Kaan, H.Y.K., Kozielski, F.

Keywords :

CELL CYCLE, MITOSIS, INHIBITOR, KSP

Exp. method :

X-RAY DIFFRACTION ( 2.750 Å )

Citation :

Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.

Wang, F.,Good, J.A.D.,Rath, O. et al.
(2012) J.Med.Chem. 55 : 1511

PDB ID: 4A51