Brand  (β version)

PDB ID: 4ZZJ

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
4TQ (3s)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-B]pyrazine-4(1h)-carboxamide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
ALY N(6)-acetyllysine
NLE Norleucine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4ZZJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : SIRT1/Activator/Substrate Complex
Release Data : 2015-07-15
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacetylase sirtuin-1 A hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2
ec: 3.5.1.-
mol_id molecule chains
2 Ac-p53 B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SIRT1, SIR2L1
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Dai, H.
Keywords : Sirtuin, Activator, Deacylase, Complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.7403 Å )
Citation :

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.

Dai, H.,Case, A.W.,Riera, T.V.  et al.
(2015)  Nat Commun  6 : 7645 - 7645

PubMed: 26134520
DOI: 10.1038/ncomms8645

Reaction

Chain : A
UniProt : Q96EB6 (SIR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:12006491, PubMed:29765047, PubMed:30409912, PubMed:32034146, PubMed:32538779
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H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O- propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - UniProtKB:Q923E4
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H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O- (2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - PubMed:28497810
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