Het-PDB Navi2 (PDB: 4ZVN)

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Ligands
Code	Name	Link
AO	Acridine orange	PoSSuM
FAD	Flavin-adenine dinucleotide	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4ZVN

Code :

4ZVN PDBj RCSB PDB PDBe

Header :

Oxidoreductase/oxidoreductase Inhibitor

Title :

Reduced quinone reductase 2 in complex with acridine orange

Release Data :

2016-03-30

Compound :

mol_id	molecule	chains	synonym
1	Ribosyldihydronicotinamide dehydrogenase [quinone]	A,B	NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
	ec: 1.10.99.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: NQO2, NMOR2 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pProEXhta

Authors :

Leung, K.K., Shilton, B.H.

Keywords :

quinone reductase 2, acridine orange, Oxidoreductase-Inhibitor complex, Oxidoreductase-oxidoreductase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.8660 Å )

Citation :

Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2.

Leung, K.K.,Shilton, B.H.
(2015) Biochemistry 54 : 7438 - 7448

Chain :

A, B

UniProt :

P16083 (NQO2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside	1.10.5.1	PubMed:18579530
	-	PubMed:18579530

PDB ID: 4ZVN