Brand  (β version)

PDB ID: 4ZVL

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Ligands
Code Name Style Show Link
AO Acridine orange PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4ZVL   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Inhibitor
Title : Oxidized quinone reductase 2 in complex with acridine orange
Release Data : 2016-04-06
Compound :
mol_id molecule chains synonym
1 Ribosyldihydronicotinamide dehydrogenase [quinone] A,B NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
ec: 1.10.99.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NQO2, NMOR2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pProEXhta
Authors : Leung, K.K., Shilton, B.H.
Keywords : quinone reductase 2, acridine orange, Oxidoreductase-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8990 Å )
Citation :

Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2.

Leung, K.K.,Shilton, B.H.
(2015)  Biochemistry  54 : 7438 - 7448

PubMed: 26636353
DOI: 10.1021/acs.biochem.5b00884

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol 1.10.5.1 PubMed:18579530
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Cofactor: Evidence: Note:
Zn(2+) - Binds 1 zinc ion per subunit.
FAD - Binds 1 zinc ion per subunit.