Brand  (β version)

PDB ID: 4ZUM

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Ligands
Code Name Style Show Link
FKS 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol PoSSuM
GOL Glycerol PoSSuM
K Potassium ion PoSSuM
NA Sodium ion PoSSuM
NO3 Nitrate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4ZUM   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : Crystal structure of acetylpolyamine amidohydrolase from Mycoplana ramosa in complex with a trifluoromethylketone inhibitor
Release Data : 2015-07-29
Compound :
mol_id molecule chains
1 Acetylpolyamine aminohydrolase A,B
Source :
mol_id organism_scientific expression_system
1 Mycoplana ramosa  (taxid:40837) Escherichia coli  (taxid:469008)
gene: aphA, aph
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-21b
Authors : Decroos, C., Christianson, D.W.
Keywords : acetylpolyamine amidohydrolase, arginase fold, enzyme-inhibitor complex, polyamine, Hydrolase-Hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.420 Å )
Citation :

Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.

Decroos, C.,Christianson, D.W.
(2015)  Biochemistry  54 : 4692 - 4703

PubMed: 26200446
DOI: 10.1021/acs.biochem.5b00536

Reaction

Chain : A, B
UniProt : Q48935 (APAH_MYCRA)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N-acetylputrescine = acetate + putrescine 3.5.1.62 PubMed:3207420, PubMed:8824626
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H2O + N-acetylcadaverine = acetate + cadaverine - PubMed:3207420, PubMed:8824626
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H2O + N(1)-acetylspermine = acetate + spermine - PubMed:3207420, PubMed:8824626
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H2O + N(1)-acetylspermidine = acetate + spermidine - PubMed:3207420, PubMed:8824626
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H2O + N(8)-acetylspermidine = acetate + spermidine 3.5.1.48 PubMed:3207420, PubMed:8824626
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