Brand  (β version)

PDB ID: 4ZS2

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Ligands
Code Name Style Show Link
AKG 2-oxoglutaric acid PoSSuM
FLU 2-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-benzoic acid PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4ZS2   PDBj   RCSB PDB   PDBe
Header : FLUORESCENT PROTEIN/INHIBITOR
Title : Structural complex of FTO/fluorescein
Release Data : 2015-11-04
Compound :
mol_id molecule chains synonym
1 Alpha-ketoglutarate-dependent dioxygenase FTO A Fat mass and obesity-associated protein
ec: 1.14.11.-
fragment: UNP residues 32-505
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FTO, KIAA1752
Authors : Wang, T., Hong, T., Huang, Y., Yang, C.G., Zhou, X.
Keywords : Inhibitor, Fluorescein, FLUORESCENT PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.16 Å )
Citation :

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Wang, T.,Hong, T.,Huang, Y.  et al.
(2015)  J.Am.Chem.Soc.  137 : 13736 - 13739

PubMed: 26457839
DOI: 10.1021/jacs.5b06690

Reaction

Chain : A
UniProt : Q9C0B1 (FTO_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate - PubMed:28002401, PubMed:30197295
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2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate 1.14.11.53 PubMed:25452335, PubMed:26457839, PubMed:30197295, PubMed:22002720
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2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate - PubMed:30197295
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2-oxoglutarate + a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate - PubMed:30197295
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2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate - PubMed:30197295
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