Brand  (β version)

PDB ID: 4ZKL

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Ligands
Code Name Style Show Link
AMP Adenosine monophosphate PoSSuM
JB6 (2r,3r,4s,5r)-2-(6-aminopurin-9-yl)-5-[2-[[(2s)-3-[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 4ZKL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)
Release Data : 2016-03-02
Compound :
mol_id molecule chains synonym
1 Histidine triad nucleotide-binding protein 1 A,B,C,D Adenosine 5'-monophosphoramidase,Protein kinase C inhibitor 1,Protein kinase C-interacting protein 1,PKCI-1
ec: 3.-.-.-
fragment: UNP residues 1-126
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: HINT1, HINT, PKCI1, PRKCNH1
expression_system_vector_type: Plasmid
expression_system_plasmid: pSGA02
Authors : Dolot, R.M., Kaczmarek, R., Seda, A., Krakowiak, A., Baraniak, J., Nawrot, B.
Keywords : HINT, HIT, Hydrolase, Phosphoramidase, Complex, AP4A analog
Exp. method : X-RAY DIFFRACTION ( 2.34 Å )
Citation :

Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

Dolot, R.,Kaczmarek, R.,Seda, A.  et al.
(2016)  Int.J.Biol.Macromol.  87 : 62 - 69

PubMed: 26905466
DOI: 10.1016/j.ijbiomac.2016.02.047

Reaction

Chain : A, B, C, D
UniProt : P49773 (HINT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine 5'-phosphoramidate + H2O = AMP + NH4(+) - PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367
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