Brand  (β version)

PDB ID: 4ZEG

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Ligands
Code Name Style Show Link
052 N-cyclopropyl-2-methyl-4-(7-{[2-(morpholin-4-yl)ethyl]amino}-5-phenoxypyrazolo[1,5-a]pyrimidin-3-yl)benzamide PoSSuM
EDO 1,2-ethanediol PoSSuM
GOL Glycerol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
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Structure summary

Code : 4ZEG   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
Release Data : 2016-04-27
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase TTK A Phosphotyrosine picked threonine-protein kinase,PYT
ec: 2.7.12.1
fragment: UNP residues 515-795
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTK, MPS1, MPS1L1
Authors : Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Battaile, K., Chirgadze, N.Y.
Keywords : Kinase, TTK, inhibitor, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.33 Å )
Citation :

Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor.

Qiu, W.,Plotnikova, O.,Feher, M.  et al.
To Be Published 

Reaction

Chain : A
UniProt : P33981 (TTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:29162720
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 PubMed:29162720
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 PubMed:29162720
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