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Ligands
Code Name Style Show Link
CO8 Octanoyl-coenzyme a
GOL Glycerol
SO4 Sulfate ion
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
Code Name Emphasize
Modification
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Code : 4ZDC   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Yeast enoyl-CoA isomerase complexed with octanoyl-CoA
Release Data : 2015-11-11
Compound :
mol_id molecule chains synonym
1 3,2-trans-enoyl-CoA isomerase A,B,C peroxisomal D3,D2- enoyl-CoA isomerase, Delta(3),Delta(2)-enoyl-CoA isomerase,D3,D2-enoyl-CoA isomerase,Dodecenoyl-CoA isomerase
ec: 5.3.3.8
other_details: CYS212 was oxidized to CME due to the presence of BME in the purification buffers.
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
gene: ECI1, YLR284C
Authors : Onwukwe, G.U., Koski, M.K., Wierenga, R.K.
Keywords : Crotonase, isomerase, octanoyl-CoA, beta-oxidation
Exp. method : X-RAY DIFFRACTION ( 2.13 Å )
Citation :

Structures of yeast peroxisomal Delta (3), Delta (2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.

Onwukwe, G.U.,Koski, M.K.,Pihko, P.  et al.
(2015)  Acta Crystallogr.,Sect.D  71 : 2178 - 2191

PubMed: 26527136
DOI: 10.1107/S139900471501559X

Chain : A, B, C
UniProt : Q05871 (ECI1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA 5.3.3.8 -
-
a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA 5.3.3.8 -
-